CrimeTelescope: crime hotspot prediction based on urban and social media data fusion

Crime is a complex social issue impacting a considerable number of individuals within a society. Preventing and reducing crime is a top priority in many countries. Given limited policing and crime reduction resources, it is often crucial to identify effective strategies to deploy the available resources. Towards this goal, crime hotspot prediction has previously been suggested. Crime hotspot prediction leverages past data in order to identify geographical areas susceptible of hosting crimes in the future. However, most of the existing techniques in crime hotspot prediction solely use historical crime records to identify crime hotspots, while ignoring the predictive power of other data such as urban or social media data. In this paper, we propose CrimeTelescope, a platform that predicts and visualizes crime hotspots based on a fusion of different data types. Our platform continuously collects crime data as well as urban and social media data on the Web. It then extracts key features from the collected data based on both statistical and linguistic analysis. Finally, it identifies crime hotspots by leveraging the extracted features, and offers visualizations of the hotspots on an interactive map. Based on real-world data collected from New York City, we show that combining different types of data can effectively improve the crime hotspot prediction accuracy (by up to 5.2%), compared to classical approaches based on historical crime records only. In addition, we demonstrate the usability of our platform through a System Usability Scale (SUS) survey on a full prototype of CrimeTelescope

Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function

Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenesis. A number of anti-TNF therapies are in current use for the treatment of RA, including certolizumab pegol (CZP), (Cimzia ®; UCB, Belgium). Anti-TNF therapy has been associated with reduced clinical cardiovascular disease risk and ameliorated vascular function in RA patients. However, the specific effects of TNF inhibitors on endothelial cell function are largely unknown. Our aim was to investigate the mechanisms underpinning CZP effects on TNF-activated human endothelial cells. Methods: Human aortic endothelial cells (HAoECs) were cultured in vitro and exposed to a) TNF alone, b) TNF plus CZP, or c) neither agent. Microarray analysis was used to examine the transcriptional profile of cells treated for 6 hrs and quantitative polymerase chain reaction (qPCR) analysed gene expression at 1, 3, 6 and 24 hrs. NF-κB localization and IκB degradation were investigated using immunocytochemistry, high content analysis and western blotting. Flow cytometry was conducted to detect microparticle release from HAoECs. Results: Transcriptional profiling revealed that while TNF alone had strong effects on endothelial gene expression, TNF and CZP in combination produced a global gene expression pattern similar to untreated control. The two most highly up-regulated genes in response to TNF treatment were adhesion molecules E-selectin and VCAM-1 (q 0.2 compared to control; p > 0.05 compared to TNF alone). The NF-κB pathway was confirmed as a downstream target of TNF-induced HAoEC activation, via nuclear translocation of NF-κB and degradation of IκB, effects which were abolished by treatment with CZP. In addition, flow cytometry detected an increased production of endothelial microparticles in TNF-activated HAoECs, which was prevented by treatment with CZP. Conclusions: We have found at a cellular level that a clinically available TNF inhibitor, CZP reduces the expression of adhesion molecule expression, and prevents TNF-induced activation of the NF-κB pathway. Furthermore, CZP prevents the production of microparticles by activated endothelial cells. This could be central to the prevention of inflammatory environments underlying these conditions and measurement of microparticles has potential as a novel prognostic marker for future cardiovascular events in this patient group. Disclosure statement: Y.A. received a research grant from UCB. I.B. received a research grant from UCB. S.H. received a research grant from UCB. All other authors have declared no conflicts of interes

Are two heads better than one? An experiment with novice share traders

We compare the performance of individual and two-person teams in an electronic share-trading task. Trader profits are negatively related to the amount of trader market activity and positively related to trader confidence. While we find no evidence of a difference in trading profit between individual and team traders, profit volatility is more sensitive to trading activity for teams. Team trading profit is positively related to attitude and negatively related to perceptions of the difficulty of the task, with overall team trading activity negatively related to views of team members'abilities

The Living Stream

IN MEMORIAM A. Norman Jeffares 11 August 1920-1 June 200